Furthermore, baseline analysis of HR+/HER2− breast cancer samples revealed that phosphorylated AKT, which is indicative of PI3K pathway activation, along with c-Myc gene amplification and elevated c-Myc protein levels, was inversely correlated with PFS in patients receiving CDK4/6 inhibitors combined with endocrine therapy54,115. This evidence concerns the gene MYC and breast carcinoma.