To elucidate the link between PRR15-induced NSCLC cell progression and the activation of the Akt-mTOR pathway, we introduced a constitutively-active mutant of Akt1 (S473D, “caAkt1”) into PRR15-silenced pNSCLC-1 cells (shPRR15-1#). The gene discussed is PRR15; the disease is non-small cell lung carcinoma.