Conversely, under pathological conditions, including IHD (i.e., AMI, cardiac I/R and post‐MI scenarios), the overwhelming activation of inflammatory caspase 1 proteolytically cleaves GSDMD to generate the carboxylic terminus (C‐terminal domain or GSDMD‐CT) and amino acid terminus (N‐terminal domain or GSDMD‐NT) [15, 22]. Here, CASP1 is linked to myocardial infarction.