To further explore the effect of CFTR modulator therapy on lung inflammation in preschool CF, we performed unsupervised hierarchical clustering analysis of median BAL analyte data from children with CF not on modulator therapy (CF.U) (n=54), children with CF on CFTR modulators LUM/IVA (LUM/IVA, n=5) or IVA (IVA, n=11) and controls (n=23). The gene discussed is CFTR; the disease is cystic fibrosis.