PCA was conducted on BAL analyte data from children with CF not on modulator therapy (denoted as CF.U, n=54); children with CF on CFTR modulator therapy LUM/IVA (denoted as CF.LUM/IVA, n=5) or IVA (denoted as CF.IVA, n=11) and age-matched controls (denoted non-CF, n=23) (figure 1B). Here, CFTR is linked to cystic fibrosis.