PCA was conducted on plasma analyte data from children with CF not on modulator therapy (CF.U, n=24); children with CF on CFTR modulator therapy LUM/IVA (CF.LUM/IVA, n=4) or IVA (CF.IVA, n=3) and age-matched controls (non-CF, n=32) (figure 2B). The gene discussed is CFTR; the disease is cystic fibrosis.