As previously shown for total H3 acetylation in non-immune yeast [25] and cancer cells [23], ACC1 inhibition not only increased nuclear H3K27 and H3K9 acetylation in iTregs after 4 days of differentiation but also increased H3K9 acetylation in TCR-activated naïve T cells (Figure 6A,B). Here, ACACA is linked to cancer.