MC4R and obesity due to leptin receptor gene deficiency: A case series including 2 children with heterozygous MC4R deficiency and 3 children with biallelic LEPR deficiency treated with methylphenidate for 12 months, showed beneficial effects as well: decrease in BMI of -0.7 ± 0.9 kg/m2 (range, +0.7 to -1.9), decrease in %BMIP95 of -6.6 ± 7.8% (range, +5 to -7) and decreased appetite, food responsiveness, and enjoyment of food (25).