Also in children with various types of genetic obesity, such as heterozygous and homozygous MC4R deficiency and 16p11.2 deletion syndrome, beneficial effects of liraglutide on body weight, cardiometabolic factors, and appetite regulation are reported (60, 61, 63, 65, 66). Here, MC4R is linked to hyperinsulinemic hypoglycemia, familial, 4.