TRIM56 and obesity due to melanocortin 4 receptor deficiency: It has been reported that obesity‐induced inflammatory status in WAT can lead to many pathogenic outcomes and impaired adaptive thermogenesis.[31] Importantly, immunohistochemical analysis indicated reduced macrophage infiltration in the WAT of TRIM56‐overexpressing mice, which is associated with improved inflammatory status and enhanced adaptive thermogenesis (Figure 4H).