Therefore, it tends to infect immunosuppressed ones, such as patients with AIDS, long-history use of immunosuppressive agents for autoimmune disease, and malignancy.[3,12] In patients with inhibitory and neutralizing autoantibodies against IFN-γ (AutoAbs-IFN-γ), recurrent and refractory NTM infections including MAC infection have been reported, with the immune disturbances remaining to be elucidated.[13]. Here, IFNG is linked to autoimmune disease.