PRLR and cancer: Other studies suggest PRL and PRLR as potential OC treatment targets.[18,25] A PRLR expression blockade could inhibit PRL-caused cancer cell proliferation.[20] Prolactin receptor antagonist (PRLRA), G129R, is a variant of human PRL that differs by a single amino acid and inhibits PRL-induced carcinogenesis signals responsible for the proliferation of malignant cells.