FLVCR2 and neoplasm: STAT3 is also involved in tumor proliferation, survival, and metastasis, and is closely related to drug resistance.[24] Research by Kasembeli et al,[16] has demonstrated that the structure and function of STAT3 in eukaryotic cells are regulated by CCT, which assists in the proper folding of unfolded or denatured STAT3 to acquire the functionality of native proteins.