CCT3 and AL amyloidosis: Additionally, a report indicated that knocking down circCCT3 (derived from exons 3–5 of CCT3 through back-splicing) inhibits the invasion of rectal cancer cells and induces apoptosis via the miR-613/WNT3 or VEGFA pathways.[55] Moreover, studies have found that the expression of CCT3 in multiple myeloma (MM) is associated with the Wnt signaling pathway.[23]