Additionally, silencing CCT3 resulted in downregulation of STAT3 and phosphorylated STAT3 (p-STAT3) expression, suggesting that CCT3 plays a key role in HCC progression by facilitating the transport of phosphorylated STAT3 from the cytoplasm to the nucleus, thus impacting the STAT3 signaling pathway. This evidence concerns the gene STAT3 and hepatocellular carcinoma.