YAP1 and hepatocellular carcinoma: Its mRNA expression is negatively correlated with DNA methylation, and the most common mutation type is missense mutations, which affect HCC development through the cell cycle and DNA replication pathways.[68] Liu Y et al[69] found that CCT3 blocks PCBP2-induced ubiquitination of YAP and TFCP2 through the βTrCP E3 ligase pathway, extending the half-life of YAP and TFCP2.