Due to the asymptomatic nature and early metastasis, most patients are diagnosed at an advanced stage, resulting in poor prognosis and often ineffective treatment.[64] As early as 2002, Midorikawa Y et al[65] detected high CCT3 expression in HCC with varying degrees of differentiation, closely correlating with tumor dedifferentiation. The gene discussed is CCT3; the disease is hepatocellular carcinoma.