In cancer, it is linked to tumor malignancy, tumor cell proliferation, apoptosis, angiogenesis, invasion, metastasis, and drug resistance.[47] Recent studies by Ren et al,[48] have shown that FBXW2 inhibits tumor cell stemness and paclitaxel resistance in breast cancer by promoting the ubiquitination of NF-κB-p65. This evidence concerns the gene NFKB1 and breast carcinoma.