VHL and cancer: Recent research has identified CCT3 as a novel regulatory factor for slc7a11, promoting tumor cell proliferation and growth through negative regulation of ferroptosis and positive regulation of the AKT signaling cascade.[31] Furthermore, CCT3 is involved in various aspects of malignant tumor cell proliferation, cell cycle regulation, apoptosis, and migration, as well as assisting in the folding of cancer-associated proteins such as p53, VHL, and STAT3.