FLT1 and hepatocellular carcinoma: In recent years, circ-CCT3, derived from the back-splicing of exons 3 to 5 of CCT3, has been found to promote HCC progression by regulating TEA domain transcription factor 1 (TEAD1) expression via sponging miR-1287-5p.[70] Furthermore, Liu H et al[71] showed that circ-CCT3 knockdown inhibits HCC growth, metastasis, invasion, and angiogenesis through the miR-378a-3p-FLT-1 pathway, and high circ-CCT3 expression is associated with poor prognosis and is an independent risk factor for overall survival in HCC patients.