This indicates that CCT3 depletion may block melanoma progression by downregulating CDK1.[34] Luo L et al[88] demonstrated that circCCT3 is highly expressed in bladder cancer, with diagnostic sensitivity of 79.5% and specificity of 65.6% in plasma tests, suggesting that plasma circCCT3 has potential diagnostic value for bladder cancer. Here, CCT3 is linked to melanoma.