CST3 and Hypertension: The causal relationship between hypertension and eGFRcystatin c was significant in both the IVW method (OR = 0.997, 95% CI: 0.995–0.999, P < .05) and the weighted median method (OR = 0.998, 95% CI: 0.996–0.999, P < .05), but not in the MR-Egger method, and the causal relationship of cystatin C levels were significantly correlated in IVW method (OR = 1.012, 95%CI: 1.000–1.024, P < .05).