After adjusting for hypertension, the link of hypertension and eGFRcystatin c (OR = 1.002, 95%CI: 0.997–1.007, P = .500) and cystatin C levels (OR = 0.988, 95% CI: 0.960–1.015, P = .378) lost statistical significance. The gene discussed is CST3; the disease is Hypertension.