The Joint British Diabetes Society‐Inpatient (JBDS‐IP) group recommends reducing fixed rate intravenous insulin infusion (FRIII) from 0.1 to 0.05 units/kg/h when blood glucose falls <14 mmol/L to reduce the risk of complications associated with acute management of diabetes‐related ketoacidosis. The gene discussed is INS; the disease is diabetes mellitus.