The evasion of fungal immune control mechanisms with down-regulated Th1 (IFN-γ, TNF-α, and IL-2) and Th17 T cell cytokines (IL-17A) and CXCR3+ T cell chemoattractant chemokine (CXCL10) responses, allows more vigorous replication of Cryptococcus and overwhelming infection. Here, TNF is linked to infection.