Additionally, increased expression of inflammasome-related markers like Absent In Melanoma 2 (AIM2), NLR Family Pyrin Domain Containing 3 (NLRP3), and GSDMD in monocyte-macrophages suggested a higher incidence of pyroptosis during severe SARS-CoV-2 compared to moderate infection (Fig 3C). This evidence concerns the gene GSDMD and infection.