In vitro studies have shown that anthocyanins activate HepG2 cells by upregulating FOXO1 and PGC-1α expression, reducing phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) activity, thus decreasing gluconeogenesis and countering insulin resistance [108–110]. Here, FOXO1 is linked to Insulin resistance.