Histone deacetylases (HDACs) are upregulated in various tumors and control the epigenetic programming to regulate cell proliferation and differentiation.[36, 37] The Class I HDACs, including HDAC1‐3, tend to promote histone deacetylation to inhibit the transcription of target genes.[12, 38] As IP‐MS data reveals that HDAC2 is a binding partner for PJA2, we focused on the oncogenic role of HDAC2 in CRC. Here, PJA2 is linked to colorectal carcinoma.