PJA2 and neoplasm: An expanding body of evidence demonstrates that the IFIT family is broadly implicated in cellular biology, encompassing processes such as apoptosis, proliferation, and tumorigenesis.[15, 16, 17] Within the realm of oncology, IFN γ has increasingly been reported as a critical driver of the tumor‐suppressive effects mediated by IFIT family proteins.[18, 19] Further in vitro phenotypic experiments showed that the knockdown of PJA2 could restore the anti‐proliferation and pro‐apoptotic effect of interferon on SW480 and RKO cells (Figure S5A,C,E, Supporting Information).