Previous reports have shown that PJA2 accelerates the ubiquitin‐related proteolysis of inhibitory PKA regulatory subunits, thereby releasing and activating the catalytic subunits and subsequent downstream pathways.[5] Additionally, PJA2 increases the ubiquitination of other functional proteins that control the tumor signaling network, metabolic reprogramming, and neuronal signal transduction.[6, 7, 8] However, the molecular mechanism of PJA2 in colorectal cancer progression remains unexplored. The gene discussed is PJA2; the disease is colorectal cancer.