HDAC2 and cancer: Previous studies have reported that HDAC2 can be regulated by ubiquitin ligases in other cancers, while the regulation of HDAC2 in CRC still lacks in‐depth research.[23, 24] With the help of the three‐dimensional structure of HDAC2 and forecast results from ubiquitination prediction databases (CPLM, Phosposite Plus, GPS‐Uber, Ubinet, and iPTM‐net), three lysine residues were predicted to contribute to the poly‐ubiquitination of HDAC2 (Figure 6E).