found increased HDAC2 expression in most human colon cancer tissues and the intestinal mucosa and polyps of APC‐deficient mice, and they demonstrated that HDAC2 is required to prevent apoptosis in colon cancer cells.[14] However, the specific molecular mechanism by which HDAC2 regulates apoptosis and its ubiquitination modification in colorectal cancer remains unclear. Here, APC is linked to malignant colon neoplasm.