TRPA1 and neoplasm: Mn2+ catalyzes H2O2 to generate ROS.[21] ROS could promote the influx of Ca2+ through stimulating the transient receptor potential A1 (TRPA1) protein, which is overexpressed in tumor cells, thereby enhancing the calcium overloading effect.[22] Therefore, nanotechnology for the sustained release of Ca2+ and the production of ROS is beneficial for enhancing anti‐tumor effects by causing mitochondrial dysfunction.[23]