In a large multicenter, placebo-controlled trial (PIVENS) of adults with MASH and without diabetes, treatment with vitamin E 800 IU daily for 96 weeks was associated with significantly greater improvement in steatohepatitis, reduction in hepatic steatosis, reduced lobular inflammation, and reduced aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels compared to placebo. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.