The relationship between obesity and insulin resistance is driven by adipose tissue inflammation, which stimulates cytokine and chemokine release [including interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), and chemokine (C-C motif) ligand 2 (CCL2)] and macrophage recruitment (9). Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.