Across the entire cohort, plasma p-tau217 was accurate in detecting AD neuropathology (ie, ADNC), including both amyloid (ie, Thal phase and Consortium to Establish a Registry of Alzheimer Disease [CERAD] score) and tau (ie, Braak stages), with the best diagnostic performance being detection of high ADNC, Thal phase greater than 3, Braak stage greater than 4, and frequent CERAD neuritic plaques (eFigures 2 and 3 in Supplement 1). Here, MAPT is linked to Alzheimer disease.