Dysfunction of the PFC, a region that is involved in emotional behavior and cognitive functions, has been associated with cognitive impairments in both FXS individuals (Wilding, Cornish, and Munir 2002; Munir, Cornish, and Wilding 2000a, 2000b; Bray et al. 2011) and in Fmr1−/y rodents (Asiminas et al. 2019; Krueger et al. 2011; Kramvis et al. 2013; Meredith et al. 2007). Here, FMR1 is linked to fragile X syndrome.