Kucharzewska et al. have reported that tumor derived exosomes, which contain MMP9, pentraxin 3 (PTX3), CD26, GLUT1, IL-8, PDGFs, caveolin 1, and lysyl oxidase mediate hypoxia-dependent intercellular signaling of highly malignant brain tumor glioblastoma multiforme [44]. This evidence concerns the gene PTX3 and glioblastoma.