Besides, proteome analysis, performed using hiTDExs collected from prostate cancer cells under hypoxic conditions revealed that hiTDExs are loaded with unique proteins (TGF-β, IL6, TNF1α, MMPs, AKT, ILK1, and β-catenin) that could enhance stemness and induce microenvironment changes; thus, promoting prostate cancer aggressiveness [15, 64]. This evidence concerns the gene TGFB1 and Familial prostate cancer.