Cytokines, associated with cancer cell immuno-resistance, like TGF-β, IL-10 and IL-1β, were higher, while antitumor cytokines, including INF-γ, TNF-α and IL-2, were lower in PC lesions compared to normal tissues with a high HIF-1α expression. The gene discussed is HIF1A; the disease is pachyonychia congenita.