The loss of exosomal miR-200b-3p release from CAFs under hypoxic conditions potentially contributes to colorectal cancer progression by increasing the stemness potential of colorectal cancer cells via upregulation of CD133, SOX2, N-cadherin, ZEB1 and E2F3, which are direct targets of miR-200b-3p [20]. The gene discussed is PROM1; the disease is colorectal cancer.