STAT3 and neoplasm: Besides, Dai et al. showed that exosomal lncRNA SNHG1 in hypoxia-induced breast cancer cells increased the levels of JAK2 and p-STAT3 by binding to miR-216b-5p in HUVECs and enhanced tumor angiogenesis and growth by regulating the miR-216b-5p/JAK2/STAT3 axis [14].