The mutation frequency of TP53 in CIN type was as high as 93.75%, and chromosome amplification was found in cell cycle regulatory genes (CCNE1, CCND1, CDK6) and some RTKs genes (EGFR, ERBB2, FGFR2, MET, RAS). This evidence concerns the gene CCNE1 and cervical squamous intraepithelial neoplasia.