The mutation frequency of TP53 in CIN type was as high as 93.75%, and chromosome amplification was found in cell cycle regulatory genes (CCNE1, CCND1, CDK6) and some RTKs genes (EGFR, ERBB2, FGFR2, MET, RAS). The gene discussed is FGFR2; the disease is cervical squamous intraepithelial neoplasia.