Instead, the CPA in this case associates with novel and rare STAT3 p.Trp37* NTD premature termination mutation; only two individuals with similar STAT3 NTD variant have been identified in gnomAD genetic database (p.Gln20Ter, p.Glu39Ter; allele frequency 1.59 × 10–6). Here, STAT3 is linked to congenital primary aphakia.