IFNA1 and Dravet syndrome: The chronic, hyperactive IFN response in DS can be attributed, at least in part, to the fact that four IFN receptors are encoded on chromosome 21: IFNAR1 and IFNAR2 for Type I IFNs (e.g. IFNβ, IFNγ), IFNGR2 for IFNγ, and the Type III subunit IL10RB for IFNλ, which also serves as a subunit of the IL10 receptor.