MTARC1 and metabolic dysfunction-associated steatohepatitis: To evaluate whether genetic deletion of Mtarc1 in mice results in hepatoprotective effects, we challenged wild-type and Mtarc1 KO mice with a high-fat, high-fructose, high-cholesterol diet also known as the Gubra Amylin NASH (GAN) diet, for 32 weeks starting at 8–10 weeks of age.