Histological analysis of hematoxylin and eosin–stained liver sections showed no significant differences in liver steatosis, inflammation, ballooning, or overall MASLD activity scores when Mtarc1 was knocked down (Figure 5H–J) but further histological evaluation of liver fibrosis revealed a significant decrease in liver collagen in Mtarc1 siRNA-treated mice (Figure 5K, L) and gene expression evaluation by quantitative polymerase chain reaction showed a significant decrease in inflammation and fibrosis-associated gene expression (Figure 5M, N). The gene discussed is MTARC1; the disease is Hepatic fibrosis.