For example, in our study, we demonstrated a significant impact of Mtarc1 KO on liver fibrosis in models with moderate to severe disease, while Smagris et al31 assessed the impact of Mtarc1 KO on liver phenotypes at later time points when the disease burden may have been too severe for loss of mARC1 to overcome. The gene discussed is MTARC1; the disease is Hepatic fibrosis.