Histological analysis and scoring of MASLD activity score revealed no significant difference between genotypes in steatosis, inflammation, and ballooning scores (Figure 3G–I) but analysis of liver fibrosis by picrosirius red staining revealed a nearly 50% reduction in liver fibrosis in Mtarc1 KO mice (Figure 3J, K). This evidence concerns the gene MTARC1 and Hepatic fibrosis.