Hence, the ratio of AG/UAG is significantly higher in dementia cases than in healthy controls, which is contradictory to the previous finding where plasma AG/UAG was found to be decreased among PDD patients [5], implicating normal functioning of the enzyme ghrelin-O-acyltransferase (GOAT), which catalyzes ghrelin acylation in this patient cohort. This evidence concerns the gene MBOAT4 and dementia.