HDAC4 and infection: The cleavage of HDAC4 induced by SVV 3Cpro was suppressed following the treatment with Lopinavir in a dose-dependent manner (Fig. 3C and D), Z-VAD-FMK has no inhibitory impact on the cleavage of HDAC4 mediated by SVV 3Cpro or SVV infection (Fig. 3E through H).