However, SY1 exerted neuroprotective effects by inhibiting reactive oxygen species (ROS) production and apoptosis in an in vitro PD model (Shishido et al., 2019), and SY1 attenuated mutant LRRK2-induced PD-like phenotypes and played a neuronal protective role in cultured cells and Drosophila (Liu et al., 2016). The gene discussed is LRRK2; the disease is Parkinson disease.