We manually inspected the 21 GWAS loci and found that the lead variants were all novel as none had not been described in the GWAS catalog for eGFR, CKD, creatinine or cystatin C levels; but two loci specific for creatinine (lead variants: rs139912558 on chromosome 11 overlapping AC090791.1, and rs117489454 on chromosome 12 overlapping RNU6-1295P) and one locus for eGFRcrecys (rs116542696 overlapping CST3) overlapped with the 513 GWAS loci identified in the bottom99 dataset (Table 2). This evidence concerns the gene CST3 and chronic kidney disease.