For example, (I) How does EXT1 remodel autophagy?, (II) As a key regulator of ER morphology and dynamic, whether EXT1 selectively targeting exogenous viral proteins is a conserved mechanism to keep the homoeostasis of ER and (III) whether the interaction of EXT1 and EXT2 impacts the EXT1’s roles in viral infection? The gene discussed is EXT1; the disease is viral infectious disease.