Intervention of the key components in the pathway could effectively attenuate senescence‐associated diseases and extend lifespan.[24] Under the context of OA, inhibition of PI3K/AKT/mTOR pathway promotes autophagy in chondrocyte and reduces the inflammatory response in the damaged joint.[25] Besides, Chen, et al.[15] recently identified an oncogenic lncRNA (LINC00511) that can promote tumor progression by modulating ADAM19 and the downstream PI3K/AKT pathway. The gene discussed is AKT1; the disease is neoplasm.