ADAM19 and neoplasm: Dysregulation of transmembrane ectodomain shedding may contribute to the tumor progression, inflammatory‐, and metabolic‐associated diseases as previously mentioned.[15, 16, 17, 35] Recently, Kong, et al.[36a,b] have shown synovial mesenchymal stem cell derived exosomal microRNA‐320c enhanced cell proliferation and chondrogenesis by reducing ADAM19 expression.