AQP4 is a key molecular component of the glymphatic system.[8c] In the context of ischemic stroke, the mislocalization of perivascular AQP4 intensifies cerebral edema and disrupts glymphatic function, leading to an accumulation of amyloid‐β and proinflammatory cytokines.[27] Functionality of the glymphatic system depends heavily on AQP4 polarization. The gene discussed is AQP4; the disease is ischemic stroke.