AQP4 and ischemic stroke: observed that brain edema diminished in AQP4 KO mice 24 h after permanent MCAO.[29] Furthermore, TGN‐020 alleviated glymphatic dysfunction by inhibiting astrocyte proliferation and AQP4 polarity at 48 h post‐MCAO/R.[28] Conversely, other studies have reported an adverse role of AQP4 in ischemic stroke pathology.