While genome-wide association studies have identified variants within the ARMS2/HTRA1 genetic locus that confer an elevated risk of AMD (11, 77), it remains challenging to pinpoint which of these 2 genes, ARMS2 or HTRA1, is primarily responsible for AMD pathology due to their linkage disequilibrium (12, 13). This evidence concerns the gene ARMS2 and age-related macular degeneration.