ARID1A and hepatocellular carcinoma: Mutations were also detected in host chromatin regulatory genes, including ARID1A, ARID1B, ARID2, MLL, MLL3, BAZ2B, BRD8, BPTF, BRE, and HIST1H4B. WGS determined that the loss of function in these genes also contributes to the progression toward HCC [63].