The results showed that gender, age, education level, living situation, daily exercise, clinical stage, disease duration, treatment method, presence of chronic diseases, BMI, hemoglobin, serum albumin, blood glucose, potassium ion concentration, magnesium ion concentration, PSQI score, and HADS score were significant factors influencing CRF in lung cancer patients (P<0.05), as shown in Table 4. The gene discussed is ALB; the disease is lung cancer.