Meanwhile, atherosclerosis-driven dysfunctional/plastic interferon- γ (IFNγ) +C-C motif chemokine receptor 5 (CCR5) + Th1-Tregs in ApoE−/− mice show reduced TIGIT expression [130], suggesting that TIGIT plays a stabilizing role in Tregs, helping to suppress inflammation [131,132]. This evidence concerns the gene APOE and atherosclerosis.