In studies evaluating LAG-3′s role in atherosclerosis, mice with LAG-3−/− bone marrow transplantation to LDLR−/− or those treated with blocking anti-LAG-3 monoclonal antibodies showed increased levels of interferon-g (IFN-γ)–producing Th1 cells and effector/memory T cells [159]. The gene discussed is LDLR; the disease is atherosclerosis.