Binary logistic regression analysis showed that complications (>2), NRS2002 score (nutritional risk), albumin (ALB), number of acute exacerbations of COPD (AECOPD) (≥2), pulmonary dysfunction (moderate to severe), and ventilator-associated pneumonia (VAP) after admission were prognostic risk factors (P<0.05). This evidence concerns the gene ALB and chronic obstructive pulmonary disease.