Sun et al. suggested that NPFF has a potential role in the anti-inflammatory field both in vitro and in vivo.19 In line with Sun et al.’s research, Wagas et al. showed that NPFF treatment increased interleukin-10 transcription and abolished interleukin-6 and tumor necrosis factor-alfa transcription and NPFFR2 was upregulated by interleukin-4, an inflammatory cytokine.19,20 We believe that increased NPFF as well as NPFFR2 levels may be a compensatory response to inflammation as a component of hypertension etiology. This evidence concerns the gene NPFFR2 and hypertensive disorder.