NGF and dementia: Studies showed that mouse NGF can prevent sustained neuronal damage by inhibiting the release of toxic amino acids, regulating cholinergic activity, inhibiting neuronal apoptosis, and other pathways.13,14,19,20,24 Chen X et al.25 demonstrated that the combination of mouse NGF and donepezil exerted therapeutic effects by inhibiting certain inflammatory cytokines in elderly dementia patients, alleviating dementia symptoms and improving cognitive function.