NGF and Parkinson disease: Since PD is also a neuroinflammatory disease,26 donepezil can successfully inhibit oxidative stress response, reduce generation of reactive oxygen species, and alleviate inflammatory symptoms.21,22,27 At the same time, NGF antagonizes excitatory amino acid toxicity, inhibits local neuroinflammatory response, and prevents secondary brain injury after acute cerebral hemorrhage.27-30 Our study further confirms the feasibility and effectiveness of adding NGF to the routine treatment of patients with PDD.