Also, we introduced 1,2,3-triazole groups with different substituents to obtain icotinib derivatives, among which compound a12 showed effective antitumor activity in non-small-cell lung cancers cells as a potent inhibitor for EGFR with IC50 value of 1.49 μM (Mao et al., 2020). This evidence concerns the gene EGFR and non-small cell lung carcinoma.