BACE1 and inherited lipid metabolism disorder: BACE and TACE secretases positively and negatively regulate NRG1 type III function, respectively.17 Of note, niacin, nicotinic acid is a TACE activator and Niaspan®, an extended-release formulation of niacin, is a FDA-approved drug used to treat dyslipidaemia in human.42-44 NRG1 type III is dispensable for myelin maintenance, whereas it is required for nerve regeneration following injury.