We already provided evidence that niacin-mediated modulation of TACE activity can be effective to ameliorate CMT neuropathies associated with excessive aberrant myelin.18 We obtained proof-of-principle of this strategy in different models of hypermyelination and aberrant myelin including Mtmr2 KO mice. The gene discussed is MTMR2; the disease is Charcot-Marie-Tooth disease.