The Stepglm[backward]+GBM model incorporated 13 genes, including ACTN4, AHNAK, ATF4, ATP1A1, B2M, CYBA, GNB2, HES1, PRNP, TMBIM6, TSPAN13, VMP1, and YWHAE, underscoring their potential as biomarkers for T2D. This evidence concerns the gene B2M and type 2 diabetes mellitus.