The Stepglm[backward]+GBM model incorporated 13 genes, including ACTN4, AHNAK, ATF4, ATP1A1, B2M, CYBA, GNB2, HES1, PRNP, TMBIM6, TSPAN13, VMP1, and YWHAE, underscoring their potential as biomarkers for T2D. The gene discussed is HES1; the disease is type 2 diabetes mellitus.