TP53 and posterior cortical atrophy: PCa has subtypes associated with HPV, such as basaloid,and nonassociatedsubtypes, such as sarcomatoid.2 HPV-relatedpenile carcinogenesis, typical of the basaloid subtype, arises fromthe overexpression of the viral oncoproteins E6 and E7, causing cellcycle dysregulation and genomic instability.13 The viral oncoprotein E6 interferes with the p53 pathway, a tumorsuppressor protein, inhibiting apoptosis by targeting the proteinfor degradation.