CDH2 and posterior cortical atrophy: Sarcomatoid PCa has a biphasic character, markedby a squamous component with sarcomatous differentiation of spindlecells.14 This epitheliomesenchymal transitionis characterized by decreased expression of E-cadherin and increasedexpression of N-cadherin, which is responsible for the mobile phenotypeof the cells.14 Cadherins are polypeptidesresponsible for epithelial intercellular adhesion, associated witha group of catenin proteins that bind the actinic microfilaments ofthe cytoskeleton.71