Changes in cytoskeletal dynamics, mediatedby changes in cadherin expression, can influence cell morphology,indicated by changes in area and volume, which express a reductionin volume and area data in the sarcomatoid group.72 AFM results (especially topography and deformation) shownanoscale changes in tumor tissues compared to the control sample.This relationship between increased deformation and nanoscale structuralchanges is strongly linked to membrane changes and, mainly, in thecomposition and arrangement of the cytoskeleton.35 Here, CDH17 is linked to neoplasm.