Zemła andco-workers demonstrated with AFM that the mostrigid conformations within the cell surface are made up of actin filaments,and the structural disarrangements in the organization of the cytoskeletonwere attributed to lower cellular rigidity, giving a mobile aspectto cancer, which correlates with the modulations caused by lossesof E-actin-bound cadherins. The gene discussed is CDH17; the disease is cancer.