Interestingly, we found that TLS in breast cancer was able to correlate with a good prognosis, which was closely associated with the density of CD103+CD8+ Trm cells and NK cell infiltration in TLS, and also found that CD103+CD8+ Trm cells and NK cells secreted a large number of effector molecules such as IFN-γ and Granzyme B. Suggesting that the CD103+ CD8+Trm cells and NK cells within TLS favor anti-tumor immune responses. The gene discussed is GZMB; the disease is breast carcinoma.