In HNSCC, c-Met inhibition demonstrated significant efficacy by reducing CAF-induced tumor growth, yielding promising results.46,82 Although the precise mechanisms of c-Met’s role in HNSCC-DR formation remain unclear, these findings, including the inhibition of CAF function, suggest a potentially critical link between c-Met and DR, particularly through its effects on CAF function. This evidence concerns the gene MET and head and neck squamous cell carcinoma.