AXIN2 and cancer: They concluded that the oncogenic activities of the Axin2-Snail axis are not limited to cancer cells but rather extend to CAFs via regulation of cytokine (CCL5 and IL-8)-mediated cancer-stromal interactions, with further implications for bone invasion and poor prognosis in oral SCC.52 On the other hand, an identifiable fibrous stroma with features of bone invasion is less frequently found in benign odontogenic epithelial tumors, such as ameloblastoma, with features of bone invasion.5 In the jaw, oral SCC can often invade the bone marrow.