Other studies comparing sepsis and non-infectious critical conditions reported distinct DNA methylation profiles affecting key genes for monocytes such as IL1A, CCL22, CCR2, and STAT3 hypermethylation and HLA-A, SOCS1, IL1R2, and CD46 hypomethylation (Lorente-Sorolla et al., 2019) as well as others genes related to immune response like C3, ANG2, MPO and LPO (Binnie et al., 2020). This evidence concerns the gene MPO and Sepsis.