Mailuo Shutong Pill (MLST) suppresses brain tissue inflammation by modulating glucose metabolism disorders, interfering with immunometabolic reprogramming, inhibiting microglia infiltration, and down-regulating the NLRP3 inflammatory vesicle signaling pathway, ultimately ameliorating cerebral ischemia–reperfusion injury (167) (Table 2). This evidence concerns the gene NLRP3 and brain ischemia.