NLRP3 stimulation contributes to ALI pathogenesis by inducing the recruitment of apoptosis-associated speck-like protein containing a CARD (ASC) and pro-caspase-1, leading to the maturation of the cytokine interleukin-1β (IL-1β) to activate the inflammatory cascade (Peng et al., 2020; Danielski et al., 2020). This evidence concerns the gene NLRP3 and acute respiratory distress syndrome.