GLP1 induces insulin secretion in relation to a meal with a low risk of hypoglycemia.3 Long-acting GLP1 receptor agonists (GLP1-RAs) are potent glucose-lowering agents and are effective in weight loss.3 The GLP1-RA semaglutide is 94% similar in structure to GLP1, with three substitutions to prolong its half-life. Here, GLP1R is linked to Hypoglycemia.