FASLG and chronic renal failure syndrome: For CD8pos T cells, our recent studies in patients with chronic kidney failure revealed an exaggerated age-independent differentiation of CD8pos RTE Tregs/Tresps via pathways 1 and 2, resulting in the enhanced production of EM Tregs/Tresps and, in particular, apoptosis-resistant CM Tresps with strong Fas ligand-mediated cytotoxicity.